Synthesis of hormone fragments
US4427827A · kind A · utility
3Cited by
3References
14Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 20, 1982 |
| Grant date | Jan 24, 1984 |
| Priority date | — |
| Expiry date | Oct 20, 2002 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The yield of peptide synthesis processes of the type in which a protected intermediate resin peptide of the formula Resin--CH.sub.2 --O--Phe--X, Resin--CH.sub.2 --O--Gly--X, Resin--CH.sub.2 --O--Ala--X, or Resin--CH.sub.2 --O--Leu--X is deprotected, and successively protected amino acids are coupled to the resin peptide and deprotected, is increased significantly by deprotecting the first residue with trifluoroacetic acid and deprotecting the other residues with hydrogen chloride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.