(Hetarylphenoxy)-(phenylpiperazinyl)-propanols, their preparation and drugs containing these compounds

US4428950A · kind A · utility

Assignee

• BASF SE

Inventors

• Albrecht Franke
• Gerd Steiner · Tauberbischofsheim, DE
• Peter C. Thieme · Monsheim, DE
• Dieter Lenke · Ludwigshafen, DE
• Josef Gries · Monsheim, DE
• Hans-Juergen Teschendorf · Dudenhofen, DE

Key dates

• Filing date: Jan 15, 1982
• Grant date: Jan 31, 1984
• Expiry date: Jan 15, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/088
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula ##STR1## where R.sup.1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.