3-O-Oleandrosyl-5-O-desosaminyl erythronolide compounds
US4429115A · kind A · utility
2Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 8, 1982 |
| Grant date | Jan 31, 1984 |
| Priority date | — |
| Expiry date | Jan 8, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/888
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The fermentation of a substrate selected among erythronolide B, erythronolide A and erythronolide A oxime with a novel mutant, Streptomyces antibioticus ATCC 31771, obtained from an industrial stock for the production of oleandomycin, said novel mutant being incapable of producing the same oleandomycin, permits novel macrolide antibiotics to be produced, having not only an activity range like that of erythromycin, but characterized by a greater stability in acidic environment, whereby for the administration of antibiotic it is no longer necessary to have recourse to esters and/or salts highly toxic for the organism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.