Patent · US Expired

Process for the removal of the formyl group from N-formyl peptides and esters thereof

US4434097A · kind A · utility

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0References

10Claims

0Family size

Assignee

Pierrel SpA · IT

Inventors

Vincenzo Giobbio · Chivasso, IT
Giorgio Ornato · Biella, IT
Livio Buracchi · Biella, IT
Alberto Mangia · Milano, IT

Key dates

Filing date	Apr 26, 1982
Grant date	Feb 28, 1984
Priority date	—
Expiry date	Apr 26, 2002

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A process for the removal of the formyl group in N-formylated peptides or their esters is described. The N-formyl compound is reacted with hydrazine or a substituted hydrazine of formula I: ##STR1## at a pH between 1 and 3.5, keeping the pH constant during the reaction. The process is particularly useful for the preparation of aspartam.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.