3.beta.,7.beta.,15.alpha.-Trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and their preparation
US4435327A · kind A · utility
9Cited by
0References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1982 |
| Grant date | Mar 6, 1984 |
| Priority date | — |
| Expiry date | Sep 21, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P33/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of 3.beta.,7.beta.,15.alpha.-trihydroxy-5-androsten-17-one and the 3,15-dipivalate thereof comprises epimerizing 3.beta.,7.alpha.,15.alpha.-trihydroxy-5-androsten-17-one in the presence of a ketone with or without a solvent, with dilute mineral acid and subsequent treatment with an organic base, and optionally subsequently esterifying the 3.beta.- and 15.alpha.-positions of the resultant 3.beta.,7.beta.,15.alpha.-triol with a reactive derivative of pivalic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.