N-Acyl-polypeptides and processes for the production thereof

US4435385A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Wilfried Bauer · Lampenberg, CH
• Janos Pless · Basel, CH

Key dates

• Filing date: Mar 2, 1982
• Grant date: Mar 6, 1984
• Expiry date: Mar 2, 2002

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

N-Acyl-polypeptides comprising the basic sequence ##STR1## wherein "Acyl" is the acyl residue of an organic or inorganic acid; A is H or alkyl; >N--CH(Z)--CO-- and E are the residues of natural .alpha.-amino acids or corresponding (D)-amino acids; C is --Trp-- or --(D)Trp--; F is a terminal grouping; and Y.sub.1 and Y.sub.2 are each H or together are a direct bond; as well as their salt forms and complexes.