Pharmacologically active 3-substituted beta-carbolines

US4435403A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Claus T. Braestrup · Copenhagen, DK
• Jogen A. Christensen · Avenue Madeleine, DK
• Mogens Engelstoft
• Gunter Neef · Berlin, DE
• Ulrich Eder · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• Wolfgang Kehr
• Dieter Palenschat

Key dates

• Filing date: Dec 17, 1981
• Grant date: Mar 6, 1984
• Expiry date: Dec 17, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-substituted beta-carbolines of the formula ##STR1## wherein R.sup.C is hydrogen, lower alkyl, alkoxyalkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms, aralkyl of up to 8 C-atoms, or (CH.sub.2).sub.n OR.sup.20 PA1 wherein R.sup.20 is alkyl of up to 6 C-atoms, cycloalkyl of 3-6 C-atoms or aralkyl of up to 8 C-atoms and n is an integer of 1 to 3; PA0 Y is oxygen, two hydrogen atoms or NOR.sup.1, PA1 wherein R.sup.1 is hydrogen, lower alkyl, aryl or aralkyl of up to 6 C-atoms, COR.sup.2, wherein R.sup.2 is lower alkyl of up to 6 C-atoms, PA0 or Y is CHCOOR.sup.3, wherein R.sup.3 is hydrogen or lower alkyl PA0 or Y is NNR.sup.4 R.sup.5, PA1 wherein R.sup.4 and R.sup.5 can be the same or different and each is hydrogen, lower alkyl, C.sub.6-10 -aryl, C.sub.7-10 -aralkyl or CONR.sup.6 R.sup.7, PA2 wherein R.sup.6 and R.sup.7 can be the same or different and each is hydrogen or lower alkyl or R.sup.4 and R.sup.5 together with the connecting N-atom, for a 5- or 6-membered heterocyclic ring which optionally may also contain an O-atom or up to 3 N-atoms and which optionally may be substituted by a lower alkyl group; PA0 Z is hydrogen, or alkoxy or aralkoxy each of up to 10 C-atoms and each…