"Ketals of 3'""-dehydrocardenolide tridigitoxosides"

US4436735A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang Schaumann · Heidelberg, DE
• Fritz Kaiser · Lampertheim, DE
• Wolfgang Voigtlander · Viernheim, DE
• Edgar Hoyer · Mannheim, DE
• Peter Neubert · Weinheim, DE

Key dates

• Filing date: Nov 5, 1982
• Grant date: Mar 13, 1984
• Expiry date: Nov 5, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R.sub.1 and R.sub.2 are identical alkyl radicals containing up to 3 carbon atoms or together represent a cyclic ketal containing 2 to 6 carbon atoms, R.sub.3 represents two hydrogen atoms, the group ##STR2## or the radical ##STR3## wherein R.sub.1 and R.sub.2 have the above-given meaning, and R.sub.4 is a hydrogen atom or a lower acyl or alkyl radical. The present invention also provides processes for the preparation of these ketals, as well as pharmaceutical compositions containing them, which are useful for the treatment of cardiac insufficiency.