Bromhexine delayed-release pharmaceutical form

US4438091A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Peter Gruber · Bottmingen, CH
• Jochen Schmid · Warthausen, DE
• Horst Lechner · Biberach, DE
• Eckhart Bauer · Biberach, DE

Key dates

• Filing date: Jun 30, 1982
• Grant date: Mar 20, 1984
• Expiry date: Jun 30, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to vehicles for the administration of bromhexine. More specifically, this invention relates to a composition for the delayed release of bromhexine which comprises (i) spheroid particles or tablets comprised of (a) bromhexine and/or acid addition salts thereof and (b) at least one pharmacologically acceptable acid or acidic substance, the total amount of acid substance from acid addition salts present and the acid or acidic substance being in a ratio of at least 2 mols to 1 mol of bromhexine, and (ii) a coating surrounding said spheroid particles or tablets, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 2 to 30 percent by weight, based upon the weight of the spheroid particles or tablets.