Organic compounds

US4438103A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Wilfried Bauer · Lampenberg, CH
• Francois Cardinaux · Reinach, CH
• Rene Huguenin · Reinach, CH
• Janos Pless · Basel, CH
• Edmond Sandrin · Frauenfeld, CH

Key dates

• Filing date: Dec 2, 1977
• Grant date: Mar 20, 1984
• Expiry date: Dec 2, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides polypeptides of formula I, EQU A--B--Gly--D--E I wherein PA0 A is Tyr or substituted Tyr, PA0 B is --Gly-- or --(D)Ala--, PA0 D is, for example, Phe or MePhe PA0 and E is, for example, --Met--X, --Leu--X,--Nle--X, --Nva--X, --Ile--X, methioninesulphoxide--X, methioninesulphone--X wherein X is --NR'R" or --OR'" and each of R', R" and R'" independently signifies hydrogen or alkyl of 1 to 5 carbon atoms, which compounds possess pharmacological activity, for example, analgesic activity.