Prostanoid compounds and pharmaceutical formulations
US4438112A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1982 |
| Grant date | Mar 20, 1984 |
| Priority date | — |
| Expiry date | Sep 17, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans --CH.dbd.CH-- or CH.sub.2 CH.sub.2 --; PA0 R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.10 where R.sup.10 is H, C.sub.1-6 alkyl or aralkyl; PA0 Y is a saturated heterocyclic amino group; and PA0 R.sup.4 is aralkyl (in which the aryl portion is substituted by alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylamino, aroylamino, phenalkyl, aminosulphonyl, alkanoylaminosulphonyl, phenylsulphonyl, nitro, tetrazolyl, substituted phenyl or thienyl). These compounds inhibit blood platelet aggregation and have bronchodilatory action, and may be formulated for use as anti-asthmatics and antithrombotic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.