.beta.-Lactam antibiotics

US4438114A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Boberg · Wuppertal, DE
• Dieter Habich · Wuppertal, DE
• Karl G. Metzger · Wuppertal, DE
• Paul Naab · Bad Reichenhall, DE

Key dates

• Filing date: Sep 7, 1982
• Grant date: Mar 20, 1984
• Expiry date: Sep 7, 2002

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A .beta.-lactam of the formula ##STR1## or a hydrate thereof, in which PA1 R represents a hydrogen atom or a methoxy group, PA1 n is 1 or 2, PA1 Z represents a group of the formula ##STR2## wherein R.sup.1 denotes an optionally substituted aryl group or an optionally substituted heterocyclyl group; PA1 or, when n is 1, PA1 Z can also represent an optionally substituted cycloalkyl group or an optionally substituted pseudoaromatic heterocyclic 5-membered or 6-membered ring, PA1 B represents an optionally substituted phenyl or cyclohexadienyl group, or an unsaturated optionally subtituted heterocyclic ring, PA1 T denotes an alkyl--CO--O--, pyridinium, aminopyridinium, carbamoylpyridinium or carbamoyloxy group, an --S--phenyl group which can be substituted, or an --S--Het group in which Het represents an optionally substituted heterocyclic 5-membered or 6-membered ring; and PA1 E represents a hydrogen atom, a pharmaceutically acceptable ester grouping a salt-forming cation or a protective group, or represents a negative charge when T contains a quaternary nitrogen, which possesses antibacterial activity rendering it useful as an antibiotic and animal feed supplement.