Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and .beta.-blocking properties, their use and pharmaceutical compositions containing them

US4438116A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Carl H. Ross · Viernheim, DE
• Wolfgang Kampe
• Wolfgang Bartsch · Viernheim, DE
• Gisbert Sponer · Hemsbach, DE
• Egon Roesch · Mannheim, DE

Key dates

• Filing date: Sep 16, 1981
• Grant date: Mar 20, 1984
• Expiry date: Sep 16, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/44
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An aminopropanol compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from hydrogen and lower alkyl; or PA1 R.sub.1 and R.sub.2 together represent an alkylene radical; PA1 R.sub.3 is hydrogen or acyl; PA1 A is one of the following structures ##STR2## wherein R.sub.4 is hydrogen or lower alkyl optionally substituted by hydroxyl halogen and lower alkylthio; and PA1 R.sub.5 and R.sub.6 are individually selected from lower alkyl; PA1 B is alkylamino which optionally carries a phenyl and a phenoxy radical optionally substituted by at at least one of halogen, hydroxyl or lower alkyl, lower acyl, lower alkylthio, acylamino, aminocarbonyl, lower alkoxy, lower alkenyloxy, phenoxy, lower alkenyl, lower alkylsulphonyl, lower alkylsulphinyl or haloalkyl; or PA1 B is an aryl- or heteroaryloxymethylpiperidine radical optionally substituted by at least one of halogen hydroxyl or lower alkyl, hydroxyl alkyl or carboxamido alkyl, or by lower alkoxy, lower acyl, amino, carboxamido, lower alkylcarbonylamido or lower alkylsulphonylamino; and the pharmacologically acceptable salts thereof, are outstandingly effective beta blockers and blood-pressure depressants.