1-Aryloxy-3-alkylamino-2-propanols and pharmaceutical compositions containing them

US4438143A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Herbert Koppe · Ingelheim am Rhein, DE
• Werner Kummer · Ingelheim am Rhein, DE
• Helmut Stahle
• Gojko Muacevic · Ingelheim am Rhein, DE
• Werner Traunecker · Münster-Sarmsheim, DE

Key dates

• Filing date: Sep 21, 1982
• Grant date: Mar 20, 1984
• Expiry date: Sep 21, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents a linear or branched alkyl of from 1 to 20 carbon atoms; PA1 R.sub.2 represents a hydrogen or halogen atom, a linear or branched alkyl or alkoxy of from 1 to 4 carbon atoms, or a divalent group --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, in which n is an integer of from 3 to 5, with the free valences bonded in the o-position relative to one another; and PA1 R.sub.3 represents a linear or branched alkyl of from 3 to 10 carbon atoms, with the provisos that R.sub.3 is not tert.butyl when R.sub.1 is ethyl or propyl and R.sub.2 is a hydrogen atom and that R.sub.3 is not isopropyl when R.sub.1 is propyl and R.sub.2 is a hydrogen atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of Formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.