Stereoselective resolution of phenylglycine derivatives with enzyme resins
US4439524A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 21, 1981 |
| Grant date | Mar 27, 1984 |
| Priority date | — |
| Expiry date | Dec 21, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/813
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a process for the stereo-selective resolution of DL-phenylglycine derivatives by hydrolyzing the ester or amide groups of N-acyl-L-phenylglycine esters or amides in N-acyl-DL-phenylglycine esters or amides by the action of enzymes, separating the N-acyl-D-phenylglycine esters or amides from the N-acyl-L-phenylglycines and then, if appropriate, subjecting the ester or amide groups of the D-enantiomers and the acyl groups to acid hydrolysis, characterized in that enzyme which are bonded to carriers are allowed to act on the N-acyl-DL-phenylglycine esters or amides in an inert two-phase mixture consisting of water-immiscible organic solvent and water.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.