Heparin esters and processes for their preparation
US4440926A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 29, 1981 |
| Grant date | Apr 3, 1984 |
| Priority date | — |
| Expiry date | Apr 29, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0075
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Esters of heparin, which are derived from heparin by replacement of the carboxyl groups of heparin by groups of the formula: ##STR1## in which R is a hydrogen atom or a methyl group and A is a hydrogen atom or a methyl, phenyl, ##STR2## X representing a chlorine atom or a nitro, alkyl containing 1 to 4 carbon atoms or methoxy group and Y representing a hydrogen or chlorine atom, the replacement being a partial or total replacement when A is other than a hydrogen atom or a methyl or phenyl group and the replacement being a partial replacement corresponding to a 10% to 90% esterification percentage of the carboxyl groups when A is a hydrogen atom or a methyl or phenyl group, and the alkali metal, alkaline earth metal, magnesium, quaternary ammonium and amine salts of the said esters. These compounds are intermediate products for preparing medicaments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.