Aroyl-aminoacids, amides and esters thereof
US4440941A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 22, 1980 |
| Grant date | Apr 3, 1984 |
| Priority date | — |
| Expiry date | Dec 22, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the structure ##STR1## wherein: Q is oxygen, sulfur or imino. PA1 X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sulfhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkysulfinyl, and alkylsulfonyl and may be the same or different; PA1 R.sub.1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylalkanoyl, or cycloalkylcarbonyl, PA1 n is an integer from 1 to 4 inclusive, PA1 R.sub.2 and R.sub.3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and substituted derivatives thereof wherein the substituents are hydroxy, amino, alkylamino, dialkylamino, alkoxy, halogen, hydroxy, mercapto, alkylmercapto and nitro, and may be the same or different; PA1 M is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, and hetero; and PA1 Z is hydroxy, amino, alkylamino, dialkylamino, or alkoxy, have angiotensin converting enzyme inhibitory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.