1H-1,2,4-Triazole-3,5-diamine derivatives and use as selective histamine H.sub.2 -antagonists

US4442110A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• John W. Clitherow · Sawbridgeworth, GB
• John Bradshaw · Solon, US
• John MacKinnon · Hertford, GB
• Barry J. Price · London, GB
• Michael Martin-Smith · Hertford, GB
• Duncan B. Judd · Ware, GB

Key dates

• Filing date: Nov 24, 1981
• Grant date: Apr 10, 1984
• Expiry date: Nov 24, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D317/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which PA1 R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, C.sub.1-10 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, trifluoroalkyl or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino or cycloalkyl, or R.sub.1 and R.sub.2 may together with the nitrogen atom to which they are attached form a 5 to 10 membered alicyclic heterocyclic ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C.sub.1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom; PA1 Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; PA1 Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, the furan ring optionally bearing a further substituent R.sub.7 adjacent to the group R.sub.1 R.sub.2 N-Alk-, or Q represents a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4…