Antibiotic bonding of vascular prostheses and other implants
US4442133A · kind A · utility
Inventors
Key dates
| Filing date | Feb 22, 1982 |
| Grant date | Apr 10, 1984 |
| Priority date | — |
| Expiry date | Feb 22, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/921
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.