Dibenzodiazepinones, pharmaceutical compositions thereof and method of use thereof

US4443452A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Wolfhard Engel
• Gunter Trummlitz · Warthausen, DE
• Gunther Schmidt · Biberach, DE
• Wolfgang Eberlein · Biberach, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Piero Del Soldato · Monza, IT

Key dates

• Filing date: Jan 31, 1983
• Grant date: Apr 17, 1984
• Expiry date: Jan 31, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of the formula ##STR1## wherein X is oxygen, --NH--, or--NCH.sub.3 --and PA0 R is 1-methyl-4-piperidinyl, 4-methyl-1-piperazinyl, endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl, or exo-8-methyl-8-acabicyclo[3.2.1]oct-3-yl, each of which may optionally have an additional methyl substitutent, a diastereomer or enantiomer thereof, or a non-toxic, pharmacologically acceptable acid addition salt thereof with an inorganic or organic acid.