Process for the production of adenine ring system containing co-enzymes bound to macromolecules

US4443594A · kind A · utility

Assignee

• Gesellschaft fur Biotechnologische Forschung mbH (GBF) · DE

Inventor

• Andreas Buckmann · Braunschweig, DE

Key dates

• Filing date: Sep 8, 1981
• Grant date: Apr 17, 1984
• Expiry date: Sep 8, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P1/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the production of adenine ring system containing co-enzymes bound to a macro-molecular carrier comprising the steps of alkylating an adenine ring system containing co-enzyme in the 1 position with an alkylating agent containing a terminal group capable of reacting with said macro-molecular carrier selected from the group consisting of carboxyl, amine and vinyl, reacting said alkylated co-enzyme with a macro-molecular carrier having groups capable of reacting with said terminal groups, subjecting said alkylated co-enzyme bound to a macro-molecular carrier to a Dimroth rearrangement into the N.sup.6 -form of alkylation, and recovering said adenine ring system containing co-enzyme bound to a macro-molecular carrier.