Liquid phase preparation of 2-H-2-oxazolines and 2-substituted-2-oxazolines
US4443611A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 7, 1982 |
| Grant date | Apr 17, 1984 |
| Priority date | — |
| Expiry date | Sep 7, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D263/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-H-2-Oxazolines are prepared by contacting in liquid phase a N-(.beta.-hydroxyalkyl)formamide with a small but catalytic amount of an inorganic zinc salt at elevated temperatures. Similarly, 2-substituted-2-oxazolines are prepared by contacting N-(2-hydroxyalkyl)carboxamides with a small but catalytic amount of an inorganic zinc salt. As an example, 2-H-2-oxazoline was prepared in approximately 72 percent yield by warming a mixture of N-(.beta.-hydroxyethyl)formamide with a catalytic amount of zinc chloride at a temperature of from 180.degree. C. to 185.degree. C./50 mm Hg for 2.2 hours. In this reaction, the desired oxazoline product was recovered as a codistillate with water during the course of the reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.