Process for the production of carnitine amide
US4443627A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 20, 1982 |
| Grant date | Apr 17, 1984 |
| Priority date | — |
| Expiry date | Jan 20, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the production of carnitine amide in the form of a chloride. The carnitine ethyl ester is obtained by reaction of 4-chloroacetoacetic acid ethyl ester with trimethyl amine and the subsequent hydrogenation is carried out with the help of a Pt/C catalyst. Such carnitine ethyl ester, without isolating it, is reacted with ammonia in an autoclave at -30.degree. to +10.degree. C. Everything is heated to 40.degree. to 80.degree. C. The mixture is stirred at such temperature at an ammoniac pressure of 8 to 24 atu. The product is filtered after cooling it to ambient temperature and counterbalancing the excess pressure. The product is then washed with alcohol and subsequently dried at 30.degree. to 50.degree. C. and at a pressure of 15 to 25 torr.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.