Selective halogenation of 2-fluoroaniline
US4443631A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 18, 1982 |
| Grant date | Apr 17, 1984 |
| Priority date | — |
| Expiry date | Jan 18, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C209/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel processes for making arylpropionic acids are described. One process comprises carboxylating particular Grignard compounds which are the products of a catalyzed reaction between corresponding arylmagnesium bromides and ethylene. Furthermore, the reaction making the particular Grignard compounds is itself novel. Also, an improved method is disclosed for making coupled aryl compounds useful as intermediates for making compounds having a pharmaceutical use. For example, particular biaryls may be used to make some of the Grignard compounds herein from which the arylpropionic acids are made. Finally, an improved bromination is disclosed giving high yields of 4-bromo-2-fluoroaniline, which is thereafter coupled with benzene, then used to make the arylmagnesium bromide reacted with ethylene to obtain the particular Grignard compound and subsequent desired arylpropionic acid, i.e. 2-(2-fluoro-4-biphenylyl)propionic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.