Substituted bromofluorobenzene derivatives and process for its manufacture

US4446075A · kind A · utility

Assignee

• Riedel-De Haen Aktiengesellschaft · DE

Inventors

• Kurt Eiglmeier · Neustadt, DE
• Reinhard Knieps · Hannover, DE

Key dates

• Filing date: Feb 20, 1981
• Grant date: May 1, 1984
• Expiry date: Feb 20, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C201/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20.degree. and 200.degree. C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.