Process for the preparation of .alpha.,.alpha.-difluoroalkyl-thiophenyl ketones
US4446078A · kind A · utility
1Cited by
15References
9Claims
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Key dates
| Filing date | Jun 28, 1982 |
| Grant date | May 1, 1984 |
| Priority date | — |
| Expiry date | Jun 28, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C319/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of .alpha.,.alpha.-difluoroalkoxy or .alpha.,.alpha.-difluoroalkylthiophenyl ketones, in which a polyhaloalkoxybenzene or a polyhaloalkylthiobenzene is reacted with a carboxylic acid, a precursor or a derivative of this acid in the presence of boron trifluoride in such an amount that the absolute pressure of the boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent. The resultant products are useful as intermediates in the synthesis of compounds having phytosanitary (e.g., herbicidal) or pharmaceutical activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.