Antigen derivatives and processes for their preparation

US4446128A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Gerhard Baschang · Bettingen, CH
• Felix M. Dietrich · Basel, CH
• Roland Gisler · Binningen, CH
• Albert Hartmann · Grenzach, DE
• Jaroslav Stanek · Arlesheim, CH
• Lajos Tarcsay · Weil am Rhein, DE

Key dates

• Filing date: May 18, 1982
• Grant date: May 1, 1984
• Expiry date: May 18, 2002

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/807
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel antigen derivatives comprising an antigen and at least one muramyl-peptide covalently bonded thereto, if appropriate via a spacer, to pharmaceutical preparations which contain such compounds and to their use as a vaccine. The novel antigen derivatives produce a pronounced increase in the immuno-response to the antigen, and in particular also a cell-medicated immunity under clinically acceptable conditions of administration.