Substituted dibenzodiazepinones

US4447434A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Gunter Trummlitz · Warthausen, DE
• Wolfhard Engel
• Wolfgang Eberlein · Biberach, DE
• Gunther Schmidt · Biberach, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Piero Del Soldato · Monza, IT

Key dates

• Filing date: Jan 31, 1983
• Grant date: May 8, 1984
• Expiry date: Jan 31, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/645
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The specification describes new substituted dibenzodiazepinones of formula ##STR1## wherein R.sub.1 is hydrogen or chlorine atom and R is (1-methyl-4-piperidinyl)methyl, (1-methyl-1,2,5,6-tetrahydro-4-pyridinyl)methyl,1-methyl-1,2,5,6-tetrahydr o-4-pyridinyl, (1-methyl-4-piperidinylidene)methyl,(2,3-dehydro-8-methyl-8-aza-bicyclo[3, 2,1]oct-3-yl)-methyl, (8-methyl-8-aza-bicyclo[3,2,1]oct-3-ylidene)-methyl or an endo-or exo-(8-methyl-8-azabicyclo[3,2,1]oct-3-yl)methyl each being optionally substituted by one or two methyls on the heterocyclic ring, and the nontoxic, pharmaceutically acceptable acid addition salts thereof, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds of formula I have an antiulcerative effect and an inhibitory effect on the secretion of gastric substances having anticholinergic activity, such as dryness of the mouth and mydriasis.