Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof

US4447622A · kind A · utility

Assignee

• Council of Scientific & Industrial Research of Rafi Marg · IN

Inventors

• Mohammad Salman · Barwala, IN
• Suprabhat Ray · Lucknow, IN
• Ved P. Kamboj · Lucknow, IN
• Nitya Anand · Lucknow, IN

Key dates

• Filing date: Sep 22, 1981
• Grant date: May 8, 1984
• Expiry date: Sep 22, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The laevo and dextro forms of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and similar derivatives thereof have substantially double the post-coital anti-fertility activity of the known racemic compound. The resolution of such known compound into the l- and d-isomeric forms may be carried out using di-p-toluoyl-l-tartaric acid monohydrate or di-p-toluoyl-d-tartaric acid.