Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
US4448715A · kind A · utility
9Cited by
47References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1981 |
| Grant date | May 15, 1984 |
| Priority date | — |
| Expiry date | Nov 2, 2001 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0825
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Novel compositions of matter of the general formula EQU A--L--Phe--L--Arg--Y are described, in which A is lower alkanoyl, pyroglutamyl, substituted with --OH or halogen, and cyclo lower alkanoyls; Y is --OH or a known tag with either radioactive, fluorogenic, chromogenic or chemiluminescent properties. The compounds of the invention are useful as novel substrates for plasma kallikrein. A new method of performing the assay for plasma kallikrein is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.