Complex of transferrin with ruthenium for medical applications
US4448762A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 3, 1980 |
| Grant date | May 15, 1984 |
| Priority date | — |
| Expiry date | Nov 3, 2000 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel Ruthenium-transferrin complex, prepared by reacting iron-free human transferrin dissolved in a sodium acetate solution at pH 7 with ruthenium by heating at about 40.degree. C. for about 2 hours, and purifying said complex by means of gel chromotography with pH 7 sodium acetate as eluent. The mono- or di-metal complex produced can be used in nuclear medicine in the diagnosis and/or treatment of tumors and abscesses. Comparative results with Ga-67-citrate, which is the most widely used tumor-localizing agent in nuclear medicine, indicate increased sensitivity of detection and greater tumor uptake with the Ru-transferrin complex.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.