Protection against dental caries
US4448768A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1981 |
| Grant date | May 15, 1984 |
| Priority date | — |
| Expiry date | Sep 18, 2001 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/825
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antigenic protein, termed antigen A, present on the cell walls and in tures of Streptococcus mutans, especially genetic group I (serotypes c, e and f) is separated from other antigenic proteins, notably those which cross-react with heart tissue, to give an antigenic preparation which may be used as a vaccine or to raise antibodies for use in protecting against dental caries. Antigen A is one of two major antigenic proteins remaining on cell walls of S. mutans genetic group I after extraction with a boiling 10 g/l liter aqueous solution of sodium dodecyl sulphate for 20 minutes. It has a molecular weight of about 29,000, an isoelectric point of 4.1 to 4.5. Its amino-acid analysis is also given. The antigen also occurs in the culture filtrate and/or cell extract and may be readily purified from these sources by, for example fractional ammonium sulphate precipitation and/or affinity chromatography on immobilized antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.