Method of using certain substituted aliphatic secondary amines or their salts for easing breathing

US4448776A · kind A · utility

Inventors

• Karl Bucher · Basel, CH
• Max Matter · Basel, CH
• Bernhard Brunner · Thun, CH
• Alfred Frey · Thun, CH

Key dates

• Filing date: Jan 20, 1982
• Grant date: May 15, 1984
• Expiry date: Jan 20, 2002

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I EQU R.sub.1 --CH(R.sub.2)--N(R.sub.3)--R.sub.4 (I) in which R.sub.1 is unsubstituted or substituted phenyl, R.sub.2 is hydrogen lower alkyl, unsubstituted or substituted phenyl or free or esterified carboxy, and in which R.sub.3 is hydrogen or lower alkyl and R.sub.4 is a group of the formula --alk.sub.1 --X--alk.sub.2 --R.sub.5, or R.sub.3 and R.sub.4 together are a group of the formula --alk.sub.3 --NH--alk.sub.4 --, alk.sub.1 and alk.sub.2 being lower alkylidene, alk.sub.3 and alk.sub.4 lower alkylene, X a direct bond, methylene or unsubstituted or substituted phenylene and R.sub.5 being hydroxy, amino or substituted amino of the formula --N(R.sub.6)--CH(R.sub.7)--R.sub.8 in which R.sub.6 is hydrogen, or, provided that R.sub.3 is hydrogen, it may alternatively be lower alkyl or unsubstituted or substituted phenyl-lower alkyl, R.sub.7 is hydrogen, lower alkyl, unsubstituted or substituted phenyl or free or esterified carboxy and R.sub.8 is unsubstituted or substituted phenyl, and their pharmaceutically acceptable salts have properties that ease breathing and are suitable for combating respiratory disorders, preferably as active ingredients in and/or for…