1-Phenylindazole-3-one compounds, process and intermediates for their preparation, and pharmaceutical compositions containing same

US4448777A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Henning Heinemann · Hannover, DE
• Daniel Jasserand · Paris, FR
• Wolfgang Milkowski
• Dimitri Yavordios · Belleville, FR
• Horst Zeugner

Key dates

• Filing date: Aug 19, 1982
• Grant date: May 15, 1984
• Expiry date: Aug 19, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New 1-phenylindazol-3-one compounds are described which have the formula I ##STR1## where R.sub.1 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy or trifluoromethyl radical, R.sub.2 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy radical, R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy or trifluoromethyl radical, R.sub.4 is a hydrogen or halogen, atom, or a lower alkyl or lower alkoxy radical, Z is an alkylene radical with 2 to 6 carbon atoms and R.sub.5 is an unsubstituted or substituted pyridyl radical, a thienyl radical or an unsubstituted or substituted phenyl radical. The compounds have pharmacological actions, for example antiallergic actions. Methods of preparing these compounds are described as well as intermediates useful in these methods. Pharmaceutical compositions containing the compounds are also described.