Patent · US Expired

7.alpha.-Alkoxycarbonyl-15.beta.,16.beta.-methylene-4-androstenes, process for the preparation thereof, and use thereof as medicinal agents

US4450107A · kind A · utility

5Cited by

3References

15Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Klaus Nickisch · Berlin, DE
Henry Laurent
Rudolf Wiechert · Berlin, DE
Jorge Casals-Stenzel · Munich, DE

Key dates

Filing date	Mar 23, 1982
Grant date	May 22, 1984
Priority date	—
Expiry date	Mar 23, 2002

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P7/10
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

7.alpha.-Alkoxycarbonyl-15.beta.,16.beta.-methylene-4-androstene compounds of Formula I ##STR1## wherein R.sup.1 is hydrogen or methyl, PA0 R.sup.2 is alkyl of 1-4 carbon atoms, PA0 X is ##STR2## and Y is carbonyl, and PA0 the bond between the C-1 and C-2 carbon atoms is a single or double bond, or PA0 when the bond between the C-1 and C-2 carbon atoms is a single bond, PA0 X can also be ##STR3## when Y is ##STR4## possess valuable pharmacological properties, e.g., as aldosterone antagonists, i.e. they reverse the effect of deoxycorticosterone on the excretion of sodium and potassium.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.