N-(4,5-Dihydro-thiazol-2-yl)-3-quinoline-carboxamides having anxiolytic activity

US4450166A · kind A · utility

Assignee

• Roussel Uclaf · FR

Inventors

• Francois Clemence · Paris, FR
• Peter F. Hunt
• Odile Le Martret · Paris, FR
• Daniel Humbert · Fontenay-sous-Bois, FR

Key dates

• Filing date: Jun 9, 1982
• Grant date: May 22, 1984
• Expiry date: Jun 9, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel N-(4,5-dihydro-thiazol-2-yl)-4-hydroxy-3-quinoline-carboxamides of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sub.1 is selected from the group consisting of hydrogen, halogen, linear alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF.sub.3 --, CF.sub.3 O--, CF.sub.3 S-- and CH.sub.3 S-- in the 6- or 7-position and their non-toxic, pharmaceutically acceptable acid addition salts having a strong anxiolytic activity and a remarkable affinity for benzodiapines receptors and their preparation.