.alpha.-Amylase inactivator, a process for its preparation, an agent based on this inactivator and its use

US4451455A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Laszlo Vertesy · Eppstein, DE
• Miroslav Mracek · Frankfurt am Main, DE
• Gerhard Braunitzer · Munich, DE
• Heinz Aschauer · Munich, DE

Key dates

• Filing date: Oct 7, 1981
• Grant date: May 29, 1984
• Expiry date: Oct 7, 2001

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

What are disclosed are two peptides having .alpha.-amylase inactivator activity, a method for making the inhibitors, in combination, by culturing Streptomyces tendae 4158 or Streptomyces tendae HAG 1226, methods for separating the combination into its two components, and methods and compositions for treating diabetes, pre-diabetes, or adiposity by administration of such peptide .alpha.-amylase inhibitors.