4(3H)-Quinazolinone derivatives, process for production thereof, and pharmaceutical compositions comprising said compounds

US4451467A · kind A · utility

Assignee

• Masayuki Ishikawa · JP

Inventors

• Masayuki Ishikawa
• Yukuo Eguchi · Chiba, JP
• Soyao Moriguchi · Yokohama, JP
• Hisashi Ebisawa

Key dates

• Filing date: Jan 6, 1982
• Grant date: May 29, 1984
• Expiry date: Jan 6, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/91
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The 4(3H)-quinazolinone compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.3, independently from each other, represent a lower alkyl group; PA1 R.sub.2 represents a lower alkoxycarbonyl group; PA1 Q represents a phenyl group or a substituted phenyl group substituted by at least one member selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, di(lower)-alkylamino groups, a methylenedioxy group, a trifluoromethyl group, a hydroxyl group, and a nitro group; PA1 R.sub.4 represents a hydrogen atom or a lower alkyl group; PA1 R.sub.5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower)alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower)alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups substituted by a member selected from the group consisting of halogen atoms, lower alkyl groups, and lower alkoxy groups;…