Acidiferous 17-normal-pentyl sparteine tartaric and fumaric acid salts pharmaceutical compositions thereof

US4451468A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Bernd Hachmeister · Hannover, DE
• Wolfgang Milkowski
• Ulrich Kuhl · Gehrden, DE
• Gerd Buschmann · Velbert, DE
• Renke Budden · Hannover, DE

Key dates

• Filing date: Sep 30, 1981
• Grant date: May 29, 1984
• Expiry date: Sep 30, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Acidiferous salts of 17-.beta.-n-pentyl sparteine are crystallized out of a solution of 17-.beta.-n-pentyl sparteine and a dicarboxylic acid selected from the group consisting of tartaric acid, fumaric acid or mixtures thereof. The novel acidiferous pentyl sparteine salts are employed in pharmaceutical compositions for the treatment of cardiac disorders and in venous therapeutical applications, and process improved stability and pharmacological properties.