2,3,4-Trinor-m-inter-phenylene-prostaglandin derivatives and compositions and method for inhibiting blood platelet aggregation
US4451483A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 1982 |
| Grant date | May 29, 1984 |
| Priority date | — |
| Expiry date | Apr 9, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C405/0041
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation, PA1 R.sup.2 and R.sup.3 each represent hydrogen or a C.sub.1-4 alkanoyl, benzoyl, substituted benzoyl, tetrahydropyranyl, ethoxyethyl or tri-(C.sub.1-4 alkyl)-silyl group, PA1 R.sup.4 is hydrogen or a C.sub.1-4 alkyl group, and PA1 R.sup.5 is a hexyl, heptyl, phenoxymethyl or m-trifluoromethylphenoxymethyl group, or PA1 R.sup.5 represents a group of the general formula ##STR2## and in this latter formula Z is an amino group or an optionally halo-substituted C.sub.1-4 alkanoylamino, benzoylamino or tosylamino group, and PA1 R.sup.6 is a C.sub.4-6 alkyl, phenyl or benzyl group, are prepared by reacting a bicyclic lactol of the formula (II), ##STR3## with a reactive phosphorane prepared from a triphenyl-m-carbobenzylphosphonium halide and a strong base, optionally esterifying the resulting prostaglandin derivative and, whenever it contains a free amino group, protecting this amino group by acylation, reacting then the prostaglandin derivative with an electr…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.