6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4452796A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 21, 1982 |
| Grant date | Jun 5, 1984 |
| Priority date | — |
| Expiry date | Oct 21, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Beta-lactamase inhibitors which are 6-alpha- and 6-beta-(aminomethyl) and (1-aminoethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof; or mixed methanediol esters with said beta-lactamase inhibitors and sulbactam. Pharmaceutical compositions comprising said beta-lactamase inhibitors and a conventional beta-lactam antibiotic, used in the treatment of bacterial infections. Compounds useful as intermediates in the synthesis of said beta-lactamase inhibitors. Antibacterial mixed bis-methanediol esters of said aminoalkyl penicillanic acid 1,1-dioxides and ampicillin or amoxicillin, also used in the treatment of bacterial infections; and intermediates therefor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.