Analgesic dipeptide amides and method of use and compositions thereof
US4454120A · kind A · utility
4Cited by
5References
39Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 24, 1982 |
| Grant date | Jun 12, 1984 |
| Priority date | — |
| Expiry date | Sep 24, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06078
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R.sub.1 TyrR.sub.2 D-Q-NR.sub.4 R.sub.5 wherein Q is Met, Met(O), Gln or Ser, R.sub.1 and R.sub.2 are each hydrogen or alkyl, R.sub.4 is phenylalkyl or substituted-phenylalkyl and R.sub.5 is hydrogen, alkyl, phenylalkyl, substituted-phenylalkyl or X-alkyl wherein X is an electronegative group are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.