.alpha..sub.2 -Adrenoceptor antagonistic benzoquinolizines
US4454139A · kind A · utility
5Cited by
0References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 9, 1982 |
| Grant date | Jun 12, 1984 |
| Priority date | — |
| Expiry date | Sep 9, 2002 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D455/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns benzoquinolizines of formula ##STR1## and their acid addition salts. In the formula R.sup.7 is lower alkyl or a phenyl or naphthyl radical optionally substituted with specified substituents and R.sup.8 is methyl or ethyl. The compounds possess high .alpha..sub.2 (presynaptic) adrenoceptor antagonistic activity and a good .alpha..sub.2 /.alpha..sub.1 antagonistic selectivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.