Allyl amine MAO inhibitors

US4454158A · kind A · utility

Assignee

• Merrell Toraude et Compagnie · FR

Inventor

• Philippe Bey · Cincinnati, US

Key dates

• Filing date: Jun 1, 1981
• Grant date: Jun 12, 1984
• Expiry date: Jun 1, 2001

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/09
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C.sub.1 -C.sub.8) alkyl, (C.sub.1 -C.sub.8)alkoxy, hydroxy, chlorine, bromine, iodine, fluorine, trifluoromethyl, nitro, (C.sub.1 -C.sub.6)alkylcarbonyl, benzoyl, or phenyl; 1-, or 2-naphthyl; 1-, 2-, or 3-indenyl; 1-, 2-, or 9-fluorenyl; 1-, 2-, or 3-piperidinyl; 2- or 3-pyrrolyl; 2- or 3-thienyl; 2- or 3-furanyl; 2- or 3- indolyl; 2- or 3-thianaphthenyl; or 2- or 3-benzofuranyl; PA1 R.sub.1 is hydrogen, (C.sub.1 -C.sub.8)alkyl, benzyl, or phenethyl; PA1 X and Y independently, are hydrogen, fluorine, chlorine, or bromine; and PA1 A is a divalent radical of the formula: ##STR2## wherein R.sub.2 is hydrogen, methyl, or ethyl, and m and n, independently, are an integer from 0 to 4, provided that m+n cannot be greater than 4; --(CH.sub.2).sub.p --D--(CH.sub.2).sub.q --, wherein D is oxygen, or sulfur, p is an integer from 2 to 4, and q is an integer from 0 to 2, provided that p+q cannot be greater than 4; or --(CH.sub.2).sub.r CH.dbd.CH(CH.sub.2).sub.s --, wherein r is an integer from 1 to 3 and s is an integer from 0 to 2, provided that r+s cannot be greater than 3; or…