Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4455317A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 23, 1981 |
| Grant date | Jun 19, 1984 |
| Priority date | — |
| Expiry date | Jun 23, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula: ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl, or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.