3-Chloro-pregnane derivatives and a process for the preparation thereof
US4456601A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1982 |
| Grant date | Jun 26, 1984 |
| Priority date | — |
| Expiry date | Oct 14, 2002 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New .DELTA..sup.1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, and PA1 Y and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen, are prepared by reacting a .DELTA..sup.1,4 -3-oxo-pregnane derivative of the general formula (II), ##STR2## wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyleneiminium salt of the general formula (III), ##STR3## wherein A.sup.(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydrolysis. The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.