Synthetic analogues of .alpha.-melanotropin
US4457864A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1981 |
| Grant date | Jul 3, 1984 |
| Priority date | — |
| Expiry date | Oct 23, 2001 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Analogues of the tridecapeptide hormone, .alpha.-melanotropin (a-melanocyte stimulating hormone, .alpha.-MSH) of the formula: EQU Ac-Ser.sup.1 -Tyr.sup.2 -Ser.sup.3 -Y.sup.4 -Glu.sup.5 -His.sup.6 -X.sup.7 -Arg.sup.8 -Trp.sup.9 -Gly.sup.10 -Lys.sup.11 -Pro.sup.12 -Val.sup.13 -NH.sub.2 wherein X and Y are amino acid residues and X is in a D-isomeric configuration. Preferred analogues, e.g. [Nle.sup.4, D-Phe.sup.7 ]-.alpha.-MSH, display increased in vitro and in vivo potency, prolongation and serum stability characteristics and may be covalently bonded to other elements or compounds (e.g., radioisotopes of iodine) without significant loss of biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.