Patent · US Expired

Androstane derivatives, process for their production, and pharmaceutical preparations containing them

US4457925A · kind A · utility

6Cited by

1References

44Claims

0Family size

Assignee

SCHERING CORPORATION · US

Inventors

Dieter Bittler · Berlin, DE
Henry Laurent
Klaus Nickisch · Berlin, DE
Rudolf Wiechert · Berlin, DE

Key dates

Filing date	Jul 29, 1982
Grant date	Jul 3, 1984
Priority date	—
Expiry date	Jul 29, 2002

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07J71/001
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Androstane derivatives of Formula I ##STR1## wherein ---- is a single bond or a double bond, PA1 R.sub.1 is methyl or ethyl, PA1 R.sup.2 is hydrogen or alkyl of 1-8 carbon atoms, PA1 --X-- is --(CH.sub.2).sub.n --, --CH.dbd.CH(CH.sub.2).sub.m --, or --C.tbd.C--(CH.sub.2).sub.m -- PA1 wherein n is 2 to 6 and m is 1 to 4, PA1 --A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --CCl.dbd.CH--, ##STR2## --U--V< is --CH.sub.2 --CH<, --CH.dbd.C<, --C(OH).dbd.C<, or --CCl.dbd.C<, and PA1 --W--Y-- is --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --C(CH.sub.3).sub.2 --, or ##STR3## with the proviso that the compound is not 17.alpha.-(3-acetoxypropyl)-17.beta.-hydroxy-4,6-androstadien-3-one, are pharmacologically efficacious compounds, e.g., are sebum suppressive.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.