Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof

US4457927A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Joachim-Friedrich Kapp · Berlin, DE
• Irmgard Bottcher · Berlin, DE

Key dates

• Filing date: Dec 22, 1982
• Grant date: Jul 3, 1984
• Expiry date: Dec 22, 2002

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/61
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrido[2,1-b]quinazolinones of the formula ##STR1## wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine; PA1 R.sub.1 is hydrogen or methyl; and PA1 R.sub.2 through R.sub.5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R.sub.2 through R.sub.5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base; possess valuable pharmacological properties.