Coupled H. influenzae type B vaccine

US4459286A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Maurice R. Hilleman · Whitemarsh, US
• Joseph Y. Tai · Fort Washington, US
• Richard L. Tolman · Hackettstown, US
• Philip P. Vella · North Wales, US

Key dates

• Filing date: Jan 31, 1983
• Grant date: Jul 10, 1984
• Expiry date: Jan 31, 2003

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Haemophilus influenzae type B polysaccharide is coupled through a spacer to a serotype outer membrane protein from Neisseria meningitidis. This conjugate has enhanced antigenicity and immunogenicity relative to the unconjugated polysaccharide.